Probing the sleep-deprived brain

first_img Study flags later risks for sleep-deprived kids Everybody loses a night of sleep sometimes — on campus, especially during exams. According to Nora D. Volkow, who gave a talk at Radcliffe’s Knafel Center Thursday titled “The Sleep-Deprived Human Brain,” a single sleepless night is probably harmless. But the cumulative effects of sleep deprivation may be more dangerous than is currently understood.Volkow, now the director of the National Institute on Drug Abuse at the National Institutes of Health, was a pioneer in positron emission tomography (PET) brain imaging, and helped carry out early studies confirming the toxic effects of cocaine. At Harvard, she reported on two sets of brain-imaging studies that shed light on the way sleep deprivation interferes with cognition, as well as its possible links to dementia and Alzheimer’s disease.Her work in drug research, she said, led to an investigation of sleep patterns. One toxic property of cocaine is that it interferes with sleep.“If you give cocaine to an animal, it is the only drug that will cause it to forgo sleep, and the animals ultimately died because they did not survive this,” she said. Yet lack of sleep itself produces some of the same adverse effects that drugs do: It disrupts memory, inhibits alertness, and can contribute to obesity. Insufficient amounts in early childhood tied to cognitive, behavioral problems As daylight saving time looms, researcher sheds light on health effects of not getting enough rest What’s another hour of lost sleep? For some, a hazard “It also results in accidents, and there are more fatalities associated with improper sleep behavior than there are with alcohol,” said Volkow, whose presentation was a 2017–2018 Kim and Judy Davis Dean’s Lecture in the Sciences..Volkow’s work included a look at the effects of sleep deprivation on the dopamine system, which regulates alertness and overall brain function. After running magnetic resonance imaging and PET scans on sleep-deprived human subjects, she found that lack of sleep inhibited certain parts of dopamine transmission: Brain cells were able to release dopamine, but not to receive it.“The decrease in dopamine receptors can be likened to going to an auditorium when nobody is there,” she said.Changes linked to sleep deprivation didn’t necessarily create tiredness, but could potentially lead to more dangerous conditions.“When people are sleep-deprived they are less likely to regulate their desires, and they engage in impulsive behaviors,” Volkow said.,One drug that appears to actually be advantageous — at least in the short term — is caffeine. Drinking coffee, she said, may temporarily increase dopamine receptors, thus countering the effects of sleeplessness.A second, as-yet-unpublished set of studies that Volkow quoted suggests a link between sleep deprivation and dementia. It is known that the brain’s glymphatic system flushes out toxins during sleep. Studies in mice have shown that fluids from blood vessels, the spine, and other parts of the body flow to the brain during sleep, helping to remove a toxic protein called beta amyloid from brain tissue. (These proteins tended to accumulate when the animal was sleep-deprived.) Unlike mice, humans can survive more than a few days without sleep, but beta amyloid buildup has been linked to dementia and Alzheimer’s disease.Volkow decided that similar studies could be done in humans. This research showed that even one night without sleep increased the accumulation of beta amyloids — though Volkow was surprised to find that the increases were found only in the right hippocampus. One night of good sleep could reverse the process, she said, but continued sleeplessness could push the toxins to dangerous levels.“We can document an association between poor sleep quality and a higher beta-amyloid burden in the brain,” she said. “This is consistent with prior reports, and we show that these are independent from the higher burden associated with genetic risks.” This, she suggested, shows a scientific reason why sleep is necessary for a healthy brain.Volkow said clinical research has too often neglected the importance of sleep, for which the evidence is clear, she added, of an important role “in the capacity of the brain to renew itself.” Calculator shows hidden costs of fatigued workforce Related Sleep deficiency in the U.S. estimated at 70 percent, with $410 billion price tag last_img read more

Mexico arrests son of Sinaloa drug cartel boss

first_imgBy Dialogo June 22, 2012 MEXICO CITY— Mexico’s military said June 21 that it had captured a son of Sinaloa drug cartel leader Joaquín “El Chapo” Guzmán, dealing a major blow against the notorious crime syndicate run by this country’s most wanted man. As billionaire head of the Sinaloa cartel, the elder Guzmán has a US$5 million reward on his head in the United States and has long sparred with U.S. and Mexican authorities. Jesús Alfredo Guzmán is “one of the main leaders of the Sinaloa cartel and a key element of the criminal organization” who was in charge of managing his father’s possessions, said José Luis Vergara, a spokesman for Mexico’s navy, as he presented the suspect to the media. The junior Guzmán was arrested in Zapopan, a municipality near Guadalajara, Mexico’s second-largest city, together with Kevin Daniel Beltrán, 19, another Sinaloa member, following an investigation conducted jointly with U.S. intelligence agencies over months, Vergara added. Jesús Alfredo Guzmán, 26, known as “El Gordo,” is wanted by the United States under an extradition request dating back to 2009. He and his wife, Alejandrina Salazar, were placed on a U.S. list of Sinaloa cartel operatives last year. In May, the U.S. Treasury Department froze the assets of the fugitive druglord’s sons Iván and Ovidio, barring Americans from doing business with them. The Treasury Department said the sons played “a significant role” in their father’s drug trafficking activities. [AFP, 22/06/2012; Elinformador.com.mx (Mexico), 22/06/2012]last_img read more

Surrey land use review set to address concerns of small firms

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Saudi Arabia asks Muslims to put hajj plans on hold amid virus

first_imgTopics : The country has put the holy cities Mecca and Medina on lockdown to prevent the virus from spreading. The hajj is due begin in late July.Mecca, birthplace of the Prophet Muhammad, is home to Islam’s holiest site inside the Grand Mosque. Medina is where Islam’s founder is buried. The umrah pilgrimage alone brought almost 7 million visitors from October 2018 to May 2019, according to government data.The hajj is obligatory for all able-bodied adult Muslim’s once in a lifetime Saudi Arabia asked Muslims to put on hold plans to perform the obligatory annual hajj pilgrimage this year as the kingdom grapples with the coronavirus.“We have asked our Muslim brothers around the world to wait” on making hajj plans “until there is clarity,” Mohammad Benten, the ninister of hajj and umrah, told state-run Al Ekhbariya TV.Saudi Arabia reported 110 cases of the virus on Tuesday, bringing the total to 1,563, including 10 deaths. Halting the hajj, which attracts millions of pilgrims to Islam’s birthplace, would be unprecedented in recent history. The kingdom suspended the lesser, non-obligatory umrah pilgrimage last month.last_img read more

Emiliano Martinez or Bernd Leno? Kevin Campbell picks who should be Arsenal’s No.1 for the upcoming Premier League season

first_imgAdvertisement Comment Emiliano Martinez or Bernd Leno? Kevin Campbell picks who should be Arsenal’s No.1 for the upcoming Premier League season Arsenal v Liverpool Mikel Arteta post match press conferenceTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 5:43FullscreenArsenal v Liverpool Mikel Arteta post match press conferencehttps://metro.co.uk/video/arsenal-v-liverpool-mikel-arteta-post-match-press-conference-2239392/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.When asked who should start in goal for the upcoming campaign, Campbell told Stadium Astro: ‘What I’ve seen from Martinez, I would go with Martinez, because I think he makes that defence a lot more settled.‘They don’t panic when he’s behind them. I’ve seen them panic when Leno’s there.’More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing Arsenal‘This is a potential banana skin for Arsenal and Mikel Arteta,’ Campbell added. ‘Martinez obviously has been at the club a long time, never really got his chance.‘Leno they brought him in, paid big money to Leverkusen, he’s come in and done fantastic.‘But at the end of last season when Martinez came in, he looked the part he performed. He’s now won two bits of silverware, Leno’s won no silverware. ‘He’s made some key decisions, his handling is very good, he comes out and makes people feel comfortable from crosses.’MORE: Kevin Campbell explains why Arsenal should keep Ainsley Maitland-NilesMORE: Amadou Diawara’s agent confirms Arsenal ‘like’ Roma midfielder amid Lucas Torreira swap deal speculationFollow Metro Sport across our social channels, on Facebook, Twitter and InstagramFor more stories like this, check our sport page Arteta has a tough decision to make (Picture: Getty Images)Arsenal hero Kevin Campbell backs Emiliano Martinez to hold onto his starting berth ahead of Bernd Leno when the Premier League resumes next month.Martinez has been at the Emirates for almost 10 years, struggling for game time at the north London club getting shipped out on six loan spells.That all changed when Leno got injured in the defeat to Brighton in June and his deputy was forced to step up into the limelight.The 27-year-old enjoyed an excellent run of form all the way through until the end of the campaign and helped fire the club to their record 14th FA Cup win.AdvertisementAdvertisementADVERTISEMENTNow, Mikel Arteta has one of the toughest choices of his managerial career to make in picking between the now fit Leno and in-form Martinez.Martinez got the nod in the Community Shield win over Liverpool on Saturday, but it remains to be seen who will be between the sticks for the Gunners’ Premier League opener against Fulham on September 12. Metro Sport ReporterSunday 30 Aug 2020 8:00 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link23Shares Advertisementlast_img read more

Ag Teacher, Manufacturing Training Leader Join Ivy Tech Regional Board

first_imgLAWRENCEBURG, Ind. — An agriculture teacher and a manufacturing training leader have been appointed to the Southeast Regional Board of Trustees for Ivy Tech Community College, filling vacancies created with the retirements of two long-serving board members.Amanda Briggs, the agriculture teacher and FFA Advisor at Madison Consolidated High School, and Brett Hofer, the Safety and Training Coordinator at Batesville Tool & Die, join a seven-member board that guides the college, which includes approving the college’s regional budget and serving as student and community advocates.Briggs and Hofer will each serve three-year terms. Ivy Tech’s state board appoints regional trustees with the aim of keeping the region in touch with local needs. Members represent various economic sectors, including commerce, manufacturing, agriculture, and education.last_img read more

Costa on target again for Blues

first_img Costa, who had opened his account in the 3-1 victory at Burnley on Monday night, was on hand to convert from close range just after the hour, which ended the brave resistance of the Foxes. Eden Hazard stroked in a second for Jose Mourinho’s men on 77 minutes. Press Association Oscar was unfortunate not to give Chelsea the lead at the start of the second half when his curling 20-yard effort came back off the inside of the far post. Ivanovic’s header was palmed away by Schmeichel from the follow-up attack. Schurrle was then flattened by a sliding challenge from Dean Hammond on the far touchline – which had the Chelsea bench remonstrating with the fourth official, but referee Mason produced only a yellow card. Leicester closed down the free-kick and broke quickly, with the ball eventually worked out to Nugent on the left side of the Chelsea penalty area. His low shot was deflcted goalwards and kicked away by Courtois. As the match opened up, Ivanovic was denied by another fine save from the Leicester keeper, this time an angled drive touched over. The visitors could have taken the lead on 55 minutes when Nugent beat the offside trap to run clear on goal, but Courtois made a smart save to push the ball wide. Almost straight away and Chelsea were in at the other end, as Cesc Fabrgeas ghosted into the right side of the Leicester penalty area, where his angled chip was palmed behind by Schmeichel. The breakthrough finally came on 63 minutes. Oscar played Ivanovic into the right side of the area, and his cutback was chested down by Costa, before the Brazil-born Spain international, signed from Atletico Madrid, drilled it past Schmeichel from six yards. Chelsea immediately made a change as Schurrle was replaced by Ramires. On 68 minutes, Leciester sent on Marc Albrighton to make his debut after joining from Aston Villa, with Mahrez coming off. Hammond was then also substituted, hobbling into the away dugout as Gary Taylor-Fletcher came on. Chelsea looked to have wrapped things up with 13 minutes left when Hazard collected the ball on the left, cut inside before drilling a low shot past Schmeichel into the corner. Stamford Bridge was soon rocking again when Didier Drogba was sent on for a cameo, the veteran striker having rejoined the club in the summer – with owner Roman Abramovich leading the applause. With two minutes left , Schmeichel tipped a 25-yard drive from substitute Willian over the crossbar. Chelsea’s £32million striker Diego Costa scored again as the Blues maintained their 100 per cent start to the Barclays Premier League season with a 2-0 win over Leicester. Leciester, back in the top flight for the first time since 2003/2004, had proved hard to break down and could have taken the lead when David Nugent was put clean through, but Belgium goalkeeper Thibaut Courtois – again picked ahead of Petr Cech – made a smart save. Both sides were positive during the opening stages, and Leicester, playing in red and having made a couple of changes from their opening-day 2-2 draw with Everton, were not looking in awe of a side expected to contest the Premier League championship once again. A deflected shot from Brazil midfielder Oscar looped up over Kasper Schmeichel and onto the roof of the net before World Cup winner Andre Schurrle drove his 20-yard effort high into the Shed End. Leicester, last season’s Championship winners, offered some threat on the break themselves. On 17 minutes, a dangerous cross from Ritchie De Laet on the overlap down the right had to be headed behind by Branislav Ivanovic. Algerian Riyad Mahrez forced a decent save from Courtois with a low strike after weaving into space at the edge of the Chelsea penalty area. Chelsea looked to step up a gear as Costa pulled the trigger from 18 yards, but Foxes captain Wes Morgan flung himself in the way to deflect the ball over. Blues boss Mourinho was out of his technical area claiming a penalty moments later when Costa went down under a strong challenge from the defender, but referee Lee Mason was unmoved, which on replays looked the correct call. last_img read more

Police chief arrested in connection with mass murder of family

first_imgAccording to reports, a municipal police chief in Mexico has been arrested for allegedly being involved in the mass murder of a family near the U.S.-Mexican border.Mexican authorities have arrested Fidel Alejandro Villegas, and authorities believe the murders were due to conflict between local drug cartels battling for control of the area.3 women, and 6 children were killed in Sonora state on November 4th.The arrest comes a month after President Donald Trump said he wanted to designate Mexican drug cartels as terrorist organizations.last_img

Hart Joins West Ham Utd on Loan

first_img“To be playing in the Premier League for a big club like West Ham, I’m really looking forward to the season,” added the player, who will be reunited with former City fullback Pablo Zabaleta at the Hammers.Hart won the Premier League twice with Manchester City, and has been capped 71 times by England, but fell out of favour after Pep Guardiola took over as manager.Although he will not play against City in the league, Hart could face his parent club as soon as Aug 4 in a pre-season friendly match in Iceland.West Ham’s season starts against Manchester United at Old Trafford nine days later.“I’ve obviously left Manchester City on loan this season, but the club as a whole, especially the supporters, have always been fantastic to me,” said Hart. “I’d never change how I feel about that club, as it’ll always be a very special club to me.“It’ll be fun to play against them because I’ll be banned when it comes to the actual season, while I’m sure Manchester United will welcome me with open arms if I get the nod and start the season away at Old Trafford.”Media reports have indicated that City will pay part of Hart’s wages under the deal.West Ham finished last season in 11th place under Croatian manager Slaven Bilic.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram England goalkeeper Joe Hart has joined West Ham United on a season-long loan from Premier League rivals Manchester City, the London club announced on Tuesday.The 30-year-old played for Torino in Italy’s Serie A last season on loan.“It’s important for me to play football, and to get the opportunity to come here and play is absolutely awesome,” he told West Ham TV.last_img read more

Mayor Wayne Messam Declares State of Emergency

first_imgMIRAMAR, Florida – As the coronavirus continues to spread throughout Florida, Mayor of Miramar, Wayne Messam declared a state of emergency for Miramar over the weekend. Below is his statement to residents of the community:Miramar Residents,As the mayor of our city and in the interest of public safety, I signed a Declaration of State of Emergency for Miramar on Saturday, March 14th.  This action was required to position our city to receive the vital resources and reimbursements for the utilization of assets and needed supplies to keep Miramar as safe as possible as we face the threats of COVID-19.Our city administration has been working very diligently over the past several weeks in preparation of this very action along with the guidance of our federal, state and county peers.I am have been in communication with Governor DeSantis and fellow mayors in Broward County as we pool information and resources as a region.Broward County has the largest number of confirmed COVID-19 confirmed cases and with Miramar being the 4th largest city in Broward, I my number one priority is public safety.In an effort to ensure public safety, please take note of the following declarative actions:As a result of my mayoral order along with the City Manager’s authority, effective this week the City of Miramar will·    Suspend senior services until further notice.·    All rentals in City facilities will be canceled or postponed. Patrons will be fully refunded for rental fees for all canceled events.·    Activities at City parks will be cancelled until further notice.·    Parents and caregivers will be required to wait in the lobby of childcare and adult daycare facilities for participants to be brought out to them.·    The Fire Department will be in contact with the State Department of Emergency Management to ensure appropriate coordination and to comply with reimbursement policies required for the State of Florida and the Federal governments.·    The Fire Department has been tasked with the purchase of all applicable tools and equipment for City use for the duration of this State of Emergency.·    All City organized sports activities suspended until further notice.·    Parks will remain open.·    Pools will remain open·    Fitness centers closed.·    PAL and Optimist canceled all activities.The below City of Miramar events will be postponed until further notice:·    Commissioner Yvette Coulborne’s Census 2020 Business Lunch and Community meeting 3/19·    Miramar Family Night, 3/20·    Paw Central Grand Opening 3/21·    Women in Fire-Rescue 2020 Summit 3/28You can be assured your city government is working diligently on behalf of our residents, corporations and city staff. Miramar has a Plan and our mission is Public Safety. Stay tuned and be informed.In Service,Mayor Wayne M. Messamlast_img read more